Following is a list of injuries and key lineup changes for games of December 30-31:
INDIANAPOLIS (10-6) AT MIAMI (11-5) on Saturday
| IND | QUESTIONABLE | WR Jerome Pathon (calf) |
| PROBABLE | LB Cornelius Bennett (hand); RB Jim Finn (shoulder); LB Dwight Hollier (shoulder); K Danny Kight (neck); TE Marcus Pollard (foot); DT Josh Williams (ankle) | |
| MIA | QUESTIONABLE | RB Rob Konrad (back); CB Terrance Shaw (knee); WR Leslie Shepherd (knee) |
| PROBABLE | G Mark Dixon (elbow); WR Oronde Gadsden (hip); S Trent Gamble (shoulder); TE Hunter Goodwin (hip); C Tim Ruddy (quad); LB Twan Russell (ankle) |
ST. LOUIS (10-6) AT NEW ORLEANS (10-6) on Saturday
| STL | QUESTIONABLE | WR Tony Horne (toe) |
| NO | OUT | RB Ricky Williams (leg) |
| DOUBTFUL | S Steve Gleason (knee); RB Terrelle Smith (back) | |
| PROBABLE | LB Phil Clarke (thigh); CB Kevin Mathis (ribs/wrist); WR Keith Poole (concussion); CB Fred Thomas (knee); WR Robert Wilson (thumb) |
DENVER (11-5) AT BALTIMORE (12-4) on Sunday
| DEN | OUT | RB Terrell Davis (lower leg) |
| QUESTIONABLE | QB Brian Griese (shoulder); WR Travis McGriff (ankle) | |
| PROBABLE | TE Desmond Clark (arm); CB Ray Crockett (hamstring); LB John Mobley (thumb) | |
| BLT | DOUBTFUL | QB Tony Banks (shoulder) |
| QUESTIONABLE | WR Billy Davis (shoulder); TE John Jones (ankle); G Edwin Mulitalo (shoulder) | |
| PROBABLE | LB Anthony Davis (thigh); QB Trent Dilfer (wrist); S Corey Harris (knee) |
TAMPA BAY (10-6) AT PHILADELPHIA (11-5) on Sunday
| TB | PROBABLE | LB Derrick Brooks (shoulder); LB Jamie Duncan (knee); DT Marcus Jones (foot); T Pete Pierson (back); LB Al Singleton (knee); C-G Todd Washington (hamstring); DE Steve White (hip); CB Floyd Young (shoulder) |
| PHI | DOUBTFUL | RB Darnell Autry (ankle) |
| PROBABLE | CB Jason Bostic (hamstring); WR Charles Johnson (shoulder); TE Chad Lewis (elbow); DT Corey Simon (back) |